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Science. 1969 Dec 12;166(3911):1417-8.

m-Hydroxyphenylacetic acid formation from L-dopa in man: suppression by neomycin.


The increased excretion of m-hydroxyphenylacetic acid in the urine of patients with parkinsonism being treated with L-dopa was reduced by gut sterilization with neomycin. The p-de-hydroxylation step is thus brought about solely by the action of gut flora; the pathway is unlikely to be involved in the events within the brain leading to the therapeutic benefit effected by L-dopa.

[Indexed for MEDLINE]

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