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Proc Natl Acad Sci U S A. 1971 Apr;68(4):773-6.

The influence of neighboring base pairs upon base-pair substitution mutation rates.

Abstract

The 2-aminopurine-induced transition, A.T --> G.C, was studied at particular sites in bacteriophage T4 as a function of the nearby base-pair composition of the DNA. Changing a base pair changed the transition rate at the adjacent base pair up to 23-fold, and at the next base pair by a lesser amount. Destabilization was achieved by replacing an A.T base pair by a G.C base pair.

PMID:
5279518
PMCID:
PMC389040
DOI:
10.1073/pnas.68.4.773
[Indexed for MEDLINE]
Free PMC Article

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