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Proc Natl Acad Sci U S A. 1970 Nov;67(3):1248-55.

The gamma-glutamyl cycle: a possible transport system for amino acids.

Abstract

Evidence is presented that rat kidney contains enzymes that catalyze the synthesis and utilization of glutathione; these reactions, which involve the uptake and release of amino acids from gamma-glutamyl linkage, constitute a cyclical process which is termed "the gamma-glutamyl cycle." The gamma-glutamyl cycle has properties that fulfill the requirements of an amino acid transport system. Thus, gamma-glutamyl transpeptidase may function in translocation and gamma-glutamylcysteine synthetase and glutathione synthetase may catalyze energy-requiring "recovery" steps in transport. These and other considerations suggest that glutathione serves a carrier function in amino acid transport.

PMID:
5274454
PMCID:
PMC283344
DOI:
10.1073/pnas.67.3.1248
[Indexed for MEDLINE]
Free PMC Article

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