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Am J Psychiatry. 1975 Nov;132(11):1204-6.

Antinuclear antibodies in chronic psychotic patients treated with chlorpromazine.

Abstract

The authors found a significantly higher incidence of antinuclear antibodies (ANA) and positive lupus erythematosus cell tests in chronic psychotic patients who received 400 mg a day or more of chlorpromazine (CPZ) for at least 7 weeks than in those who had taken 50 to 300 mg a day for varying periods or those who had received no CPZ for at least 3 months. Despite the high incidence of ANA, there was no observed development of lupuslike syndrome. The authors suggest that CPZ in high doses may induce ANA in humans.

PMID:
52302
DOI:
10.1176/ajp.132.11.1204
[PubMed - indexed for MEDLINE]
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