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Rev Tuberc Pneumol (Paris). 1971 Nov;35(7):695-712.

[Rifampicin, pregnancy, hormonal contraception, menopause and aging].

[Article in French]

Abstract

PIP:

Rifampicin (usually 600 mg per day, with ethambutol 1 gm or isoniazide) was given to 106 patients with tuberculosis: 6 during pregnancy, 4 of whom were taking estrogen and progestagens for hormonal imbalance , 14 women taking oral contraceptives or steroids, 25 women with increased estrogen levels, and 5 elderly women taking testosterone. Particular attention was paid to liver function considering reports of jaundice in pregnancy, oral contraception, and use of rifampicin with isoniazide. The 6 pregnancies resulted in 5 normal infants (1 with meconium staining) and 1 fetal death at 6 months. During pregnancy there were 3 incidents of elevated serum glutamic-pyruvate transaminase (SGPT) 30-150 units, and 1 of liver toxicity. The authors' concluded that there was no proof that rifampicin caused the hormonal imbalance or fetal death, and it can be prescribed safely, especially after the first 3 months. In 12 progestagen and estrogen users, there were 1 jaundice treated by stopping rifampicin but not the pill, and 4 incidents of elevated SGPT of 35-90 units. The authors recommended following those taking pills and rifampicin with regular SGPT tests. 5 patients received cyclofenil, 400 or 800 mg per day, in addition to rifampicin to induce ovulation or treat menopausal symptoms: this resulted in 1 case of hepatic toxicity. Cyclofenil is preferred over estrogen for treating menopausal symstoms in patients on rifampicin. 5 postmenopausal women received methyl-testosterone and ethinyl estradiol without any change in SGPT.

PMID:
5151212
[Indexed for MEDLINE]

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