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Science. 1972 Aug 4;177(4047):442-4.

Water-soluble derivatives of 1 -tetrahydrocannabinol.

Abstract

Delta1-Tetrahydrocannabinol, which is resinous and insoluble in water and therefore difficult to study pharmacologically, can be converted to a watersoluble derivative without loss of its biological activity. This has been achieved by preparing esters bearing a nitrogen moiety with the use of carbodiimide as the condensing agent. The availability of such water-soluble derivatives will allow the evaluation of Delta1-tetrahydrocannabinol in self-administration studies in monkeys for its addiction liability potential in man. This technique of water solubilization is also applicable to other compounds of chemical and biological significance.

PMID:
5043146
DOI:
10.1126/science.177.4047.442
[Indexed for MEDLINE]

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