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Hum Genet. 1979 Sep;50(3):307-12.

Determinants of plasma uric acid.

Abstract

Obesity, alcohol consumption, and hematocrit provide an index of plasma uric acid, which in path analysis has a cultural heritability of 0.11 in children and 0.23 in parents, a small maternal effect, and a genetic heritability of 0.25 in both generations. Preliminary evidence for a major locus is destroyed by the omission of one exceptional child. There is no evidence against the polygenic hypothesis for hyperuricemia in the Japanese-American population studied.

PMID:
489016
DOI:
10.1007/bf00399397
[Indexed for MEDLINE]

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