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Ann Clin Res. 1974 Feb;6(1):40-4.

The effect of the copper-T 200 IUD on the luteal phase plasma progesterone concentration in the normal menstrual cycle.



Plasma progesterone levels were measured by the competitive protein binding assay during the luteal phase of the menstrual cycle to investigate the possibility that the Copper-T (IUD) had a luteolytic effect. 26 women (ages 23-35) were studied for 17 IUD cycles and 18 control cycles. Cycle length of ovulation cycles was nearly identical between control and IUD cycles (28.8 days control vs 28.5 IUD) but IUD cylces were 59% ovulatory compared with 78% ovulatory cycles in the control group. The mean of the peak plasma progesterone level was the same in both groups for ovulatory cycles (15ng/ml). The peak level occurred 1 to 2 days earlier in the control than in the IUD cycles and the plasma progesterone decreased 1 to 2 days earlier in the control than in the IUD cycles. The plasma progesterone level was significantly higher (p.005) in the IUD cycles (7.4 plus or minus than in the control cycles (2.6'ng/ml). (2.6 plus or minus length of the luteal phase was the same in the IUD as in the control cycle according to progesterone levels. Progesterone secretion by the corpus luteum was not affected by the Copper-T 200 IUD.

[Indexed for MEDLINE]

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