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Br Med J. 1973 Nov 17;4(5889):382-4.

Use of 5-fluorocytosine in patients with impaired renal function.

Abstract

The plasma level and elimination of 5-fluorocytosine (5-FC) was measured in normal subjects and patients with impaired renal function. Prolongation of the half-life of the drug in renal failure has been confirmed. Renal clearance of 5-FC was about 75% of the creatinine clearance and a corresponding modification of drug dosage should be made in patients with renal insufficiency.

PMID:
4749757
PMCID:
PMC1587832
DOI:
10.1136/bmj.4.5889.382
[Indexed for MEDLINE]
Free PMC Article

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