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J Physiol. 1972 Dec;227(3):769-800.

Receptive field organization of 'sustained' and 'transient' retinal ganglion cells which subserve different function roles.

Abstract

1. Post-stimulus histograms were obtained from ;sustained' and ;transient' retinal ganglion cells for receptive field plots using a light spot with square-wave modulation of intensity, and of variable intensity and area. Fundamental differences in their receptive field organization in time and space were revealed.2. In ;sustained' cells, excitation consists of ;transient' and ;sustained' components and the ratio of transient/sustained components remains constant at a given retinal locus for a wide range of intensities. The transient component becomes proportionally larger towards the periphery of the receptive field. This rule is also applicable for the inhibitory and disinhibitory surround. In ;transient' cells, however, there is no true ;sustained' component, but some cells produce a double peaked transient post-stimulus histogram at the R.F. centre when high flux stimuli are used, while others show a single peak transient response. The magnitude and shape of transient responses changes with intensity as well as with location in the receptive field.3. The sensitivity gradients of ;sustained' and ;transient' cells show consistent differences in shape. The mean slope of the sensitivity gradients of a sample of ;sustained' cells was 10 times that of a sample of ;transient' cells. The sensitivity gradient of ;sustained' cells shows a distinct surround region where the inhibitory mechanism is more sensitive, while that of ;transient' cells usually does not, owing to an extensive ;tail' on the sensitivity gradient of the centre mechanism, which overlaps the surround.4. Ricco's Law also holds for the centre mechanism of ;transient' cells. Non-linear summation occurs at supra-threshold levels, and when the surround mechanisms are involved.5. Supra-optimal stimuli give a saturation of the response in both ;transient and ;sustained' cells. This saturation is associated with a decrease of latency in ;transient' cells, but not in ;sustained' cells.6. The latency of retinal ganglion cells is determined by both stimulus and background flux. The effect of the background is negligible except at low values of stimulus flux, where its effect may be analysed primarily in terms of its effect on the incremental threshold.7. The latency to stimulation with a standard small spot (25-27') at the receptive field centre is shorter for ;sustained' cells than for ;transient' cells; this latency difference being related to the greater sensitivity of the ;sustained' cells to stimuli of this size. Differences in conduction time along ;transient' and ;sustained' pathways to the lateral geniculate nucleus (LGN) and cortex were estimated, and it is concluded that despite the latency difference noted above, a response to a stimulus which is optimal for a ;transient' cell reaches the cortex faster than the response to a stimulus which is optimal for a ;sustained' cell.8. The above results together with previous evidence available suggest that for most stimuli, centre and surround mechanisms are activated simultaneously and algebraically summed by a single linear stage in ;sustained' cells. In ;transient' cells, although the centre excitation and surround inhibition pools are also spatially co-extensive, they summate and interact in time and space with a greater complexity.9. Differences in the receptive field organization of ;sustained' and ;transient' cells may reflect their different functional roles in vision: (1) analysis of spatial contrast and form recognition (;sustained' cells), and (2) fast detection of objects entering visual space to cause orientation responses (;transient' cells).

PMID:
4654257
PMCID:
PMC1331286
DOI:
10.1113/jphysiol.1972.sp010058
[Indexed for MEDLINE]
Free PMC Article

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