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Proc Natl Acad Sci U S A. 1974 Jan;71(1):89-92.

The requirement for ribosomal proteins L7 and L12 in peptide-chain termination.

Abstract

Proteins L7 and L12 from 50S ribosomal subunits of Escherichia coli are required for peptidechain termination. This termination process is inhibited by thiostrepton. Since both thiostrepton-treated ribosomes and those depleted of L7 and L12 have a markedly reduced ability to form release factor.UA[(3)H]A.ribosome complexes, the binding of release factors to the ribosome appears to be the primary site of inhibition.

PMID:
4589896
PMCID:
PMC387938
[Indexed for MEDLINE]
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