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Gastroenterology. 1978 Jul;75(1):95-9.

Hypersensitivity reaction to sulfasalazine with severe hepatotoxicity.

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Georgetown University Medical Division, District of Columbia General Hospital, Washington 20003.


Sulfasalazine hepatotoxicity has been poorly documented in the literature. We report a case of a young female with inflammatory bowel disease who developed severe hepatotoxicity as part of a systemic hypersensitivity reaction to sulfasalazine. The clinical, biochemical, and histopathological features resemble those of sulfonamide-induced hepatic injury. Although rare, our case as well as previous reports indicate the serious nature of the illness.

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