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Proc Natl Acad Sci U S A. 1974 Dec;71(12):4693-7.

Sites of acetylation of sickle cell hemoglobin by aspirin.

Abstract

Aspirin acetylates a variety of sites on both the alpha and beta chains of hemoglobin S. Nevertheless, the vast majority of acetyl groups become attached to three loci: betaLys 59, betaLys 144, and alphaLys 90. These observations reveal some molecular details of this transacylation reaction and suggest interesting possibilities for its extension to other acylsalicylates with a variety of different structures.

PMID:
4531009
PMCID:
PMC433962
DOI:
10.1073/pnas.71.12.4693
[Indexed for MEDLINE]
Free PMC Article

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