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Proc Natl Acad Sci U S A. 1974 Jun;71(6):2169-73.

Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species.

Abstract

The ability of fibroblasts to perform unscheduled DNA synthesis (a measure of excision-repair) after UV irradiation was measured radioautographically for seven species at several times after several UV fluences. Both the initial rate and the maximum incorporation of [(3)H]dThd increased with the life-span of the species (shrew, mouse, rat, hamster, cow, elephant, man). Unscheduled DNA synthesis was approximately proportional to the logarithm of life-span.

PMID:
4526202
PMCID:
PMC388412
[Indexed for MEDLINE]
Free PMC Article

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