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Proc Natl Acad Sci U S A. 1974 Apr;71(4):1193-6.

Adriamycin and daunorubicin inhibition of mutant T4 DNA polymerases.

Abstract

The anticancer drugs, adriamycin and daunorubicin, as well as two other DNA reagents, ethidium bromide and 9-aminoacridine, all exert a differential inhibitory effect on nucleotide incorporation for purified DNA polymerases induced by mutant and wild-type bacteriophage T4. When compared with DNA polymerase of wild-type phage, antimutator enzymes are inhibited to a far greater extent and mutator enzymes to a lesser extent. In contrast, the polymerase-associated 3'-exonuclease activities of wild type and mutants are also inhibited by the compounds but nondifferentially.

PMID:
4524632
PMCID:
PMC388190
DOI:
10.1073/pnas.71.4.1193
[Indexed for MEDLINE]
Free PMC Article

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