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Proc Natl Acad Sci U S A. 1974 Apr;71(4):1133-6.

The effect of replacement of methionine by homocystine on survival of malignant and normal adult mammalian cells in culture.

Abstract

In tissue cultures of normal adult and malignant mammalian cells, homocystine has been substituted for methionine in a medium rich in folic acid and cyanocobalamin. Normal adult cells thrive. Three highly malignant cell types from three different species, including man, die.

PMID:
4524624
PMCID:
PMC388177
[Indexed for MEDLINE]
Free PMC Article
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