Combined oral L-dopa and propranolol for growth hormone provocation

South Med J. 1979 Jul;72(7):842-4. doi: 10.1097/00007611-197907000-00023.

Abstract

A convenient test of growth hormone (GH) provocation using oral doses of L-dopa and propranolol (L + P) is compared with insulin-induced hypoglycemia (IIH) in 28 children and adolescents with short stature. In eight of these children, growth hormone deficiency was diagnosed when GH failed to rise above 7 ng/ml. The GH levels of the remaining GH-responsive children were significantly higher after administration of L + P (P less than .05) when compared with IIH given before L + P on the same morning or on a separate day.

MeSH terms

  • Child
  • Growth Hormone / deficiency
  • Growth Hormone / metabolism*
  • Humans
  • Hydrocortisone / blood
  • Hypoglycemia
  • Insulin / pharmacology
  • Levodopa / administration & dosage
  • Levodopa / pharmacology*
  • Propranolol / administration & dosage
  • Propranolol / pharmacology*

Substances

  • Insulin
  • Levodopa
  • Growth Hormone
  • Propranolol
  • Hydrocortisone