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Br J Pharmacol. 1974 Jul;51(3):453-55.

Sensitization of noradrenaline responses by inhibitors of extraneuronal uptake in a coronary artery preparation.


Inhibition of neuronal uptake with cocaine had no significant effect on the dose-response curve to noradrenaline in strips of beef coronary artery. However, responses were enhanced about 3-fold by 17beta-oestradiol and the haloalkylamine GD-131, two known inhibitors of extraneuronal uptake.

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