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Pediatrics. 1979 Mar;63(3):483-5.

A decongestant-antihistamine mixture in the prevention of otitis media in children with colds.


One hundred four preschool-age patients in a private pediatric practice were treated prospectively during colds with either decongestant-antihistamine or placebo to determine if the decongestant-antihistamine mixture was effective in the prevention of otitis media. Each child received a standard dosage of the study medicine according to a double-blind, crossover design. Otitis media was diagnosed on the basis of clinical criteria. Fifteen (6.4%) of 234 colds treated with placebo and 14 (5.8%) of 241 colds treated with the study drug were followed by otitis. The decongestant-antihistamine mixture was not useful in preventing development of otitis media in children with colds.

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