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Science. 1974 Nov 1;186(4162):449-51.

Cyclic guanosine monophosphate: elevation in degenerating photoreceptor cells of the C3H mouse retina.


As a result of an early deficiency in cyclic nucleotide phosphodiesterase activity, guanosine 3',5'-monophosphate accumulates in retinal photoreceptor cells before they begin to degenerate. It is suggested that degeneration of the photoreceptor cells is related to an imbalance in their metabolism or function which is caused by the elevated levels of cyclic guanosine monophosphate.

[Indexed for MEDLINE]

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