Isolated growth hormone deficiency. Two families with autosomal dominant inheritance

Arch Dis Child. 1974 Jan;49(1):55-9. doi: 10.1136/adc.49.1.55.

Abstract

Two families, each with a father and a son affected by isolated growth hormone deficiency, are described. The inheritance in these cases seems to be due to an autosomal dominant gene. Isolated growth hormone deficiency appears to be a heterogeneous condition.

MeSH terms

  • Adolescent
  • Adrenocorticotropic Hormone / therapeutic use
  • Adult
  • Age Determination by Skeleton
  • Blood Glucose / analysis
  • Body Height
  • Body Weight
  • Child
  • Child, Preschool
  • Cholesterol / blood
  • Dwarfism, Pituitary / genetics*
  • Genes, Dominant*
  • Glucose Tolerance Test
  • Growth / drug effects
  • Growth Hormone*
  • Humans
  • Infant
  • Infant, Newborn
  • Insulin / metabolism
  • Male
  • Middle Aged
  • Puberty
  • Radioimmunoassay
  • Testosterone / therapeutic use

Substances

  • Blood Glucose
  • Insulin
  • Testosterone
  • Adrenocorticotropic Hormone
  • Growth Hormone
  • Cholesterol