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Science. 1973 Dec 7;182(4116):1026-8.

Hepatitis A: detection by immune electron microscopy of a viruslike antigen associated with acute illness.


Spherical 27-nanometer particles were visualized in stools obtained from hepatitis A patients in the acute phase of the disease. The particle was serologically specific for this disease, and every hepatitis A patient tested demonstrated a serologic response to this antigen. The findings suggest that it is the etiologic agent of hepatitis A.

[Indexed for MEDLINE]

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