Location of the second gene required for expression of the leukemia-associated mouse antigens G IX

E Stockert; H Sato; K Itakura; E A Boyse; L J Old; J J Hutton

doi:10.1126/science.178.4063.862

Location of the second gene required for expression of the leukemia-associated mouse antigens G IX

Science. 1972 Nov 24;178(4063):862-3. doi: 10.1126/science.178.4063.862.

Authors

E Stockert, H Sato, K Itakura, E A Boyse, L J Old, J J Hutton

PMID: 4343697
DOI: 10.1126/science.178.4063.862

Abstract

Some mouse strains express G(IX) antigen on their thymocytes; others do not. Expression depends on two genes, Gv-1 and Gv-2, in linkage groups IX and I, respectively. Cells producing leukemia virus, however, express G(IX) antigen regardless of their inherited Gv-1 and Gv-2 genotype.

MeSH terms

Animals
Antigens, Neoplasm / analysis*
Antigens, Viral / analysis*
Chromosome Mapping
Crosses, Genetic
Genes*
Genetic Linkage
Genotype
Leukemia Virus, Murine / immunology
Leukemia, Experimental / immunology*
Mice
Mice, Inbred C57BL
Phenotype
T-Lymphocytes / immunology
Thymus Gland / immunology*

Substances

Antigens, Neoplasm
Antigens, Viral