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Science. 1972 Jul 14;177(4044):175-7.

Pitting function of the spleen in malaria: ultrastructural observations.

Abstract

Ultrastructural studies of spleens from monkeys infected with Plasmodium knowlesi suggest that the spleen removes or "pits" malaria parasites from red cells. This function may explain the presence of nonparasitized spherocytic erythrocytes in the peripheral blood and may in part account for the discrepancy between the excessive hemolysis and the number of parasitized erythrocytes in animals with experimentally induced malaria.

PMID:
4339353
DOI:
10.1126/science.177.4044.175
[Indexed for MEDLINE]

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