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Science. 1969 Aug 1;165(3892):513-5.

Human growth hormone release: relation to slow-wave sleep and sleep-walking cycles.


Release of human growth hormone during sleep is significantly related to slow, synchronized stages of sleep and therefore would seem to be controlled by related neural mechanisms. When sleep-waking cycles are reversed by 12 hours, the release of growth hormone with sleep is reversed; thus release does not follow an inherent circadian rhythm independent of sleep.

[Indexed for MEDLINE]

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