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Experientia. 1979 Dec 15;35(12):1657-8.

Increased release of tumour cells by collagenase at acid pH: a possible mechanism for metastasis.

Abstract

The ability of collagenase to disaggregate a solid metastasizing lymphosarcoma has been shown to considerably increase with reducing environmental pH. It is suggested that this effect may be operating in vivo to release cells from a primary tumour.

PMID:
42555
DOI:
10.1007/bf01953252
[Indexed for MEDLINE]

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