Format

Send to

Choose Destination
J Med Chem. 1979 Jan;22(1):109-11.

Phosphonate analogue of 2'-deoxy-5-fluorouridylic acid.

Abstract

The phosphonate analogue (6) of 2'-deoxy-5-fluorouridylic acid has been prepared via a Pfitzner--Moffatt oxidation and Witting reaction. This compound was found to inhibit thymidylate synthetase from three sources and to be cytotoxic to H.Ep.-2 cells in culture.

PMID:
423172
DOI:
10.1021/jm00187a024
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center