Vi antigen from Salmonella typhosa and immunity against typhoid fever. I. Isolation and immunologic properties in animals

Infect Immun. 1974 Feb;9(2):348-53. doi: 10.1128/iai.9.2.348-353.1974.

Abstract

The role of Vi antigen in human immunity against typhoid fever has been debated for decades. Circumstantial evidence indicates that Vi antigen may play a role in pathogenicity and immunity. A Vi preparation was isolated from Salmonella typhosa, the causative organism in human typhoid fever, by a mild precipitation method. It was significantly more potent in animal studies than preparations from Citrobacter used in the past for human study and less toxic than conventional typhoid vaccines. With this antigen, the role of Vi antigen in human protection is now being investigated.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antigens, Bacterial / analysis
  • Antigens, Bacterial / isolation & purification*
  • Antigens, Bacterial / toxicity
  • Chemical Precipitation
  • Complement System Proteins
  • Dactinomycin / pharmacology
  • Escherichia / immunology
  • Goats / immunology
  • Hemagglutination Tests
  • Immunodiffusion
  • Lethal Dose 50
  • Lymphocyte Activation
  • Male
  • Methods
  • Mice
  • Polysaccharides / analysis
  • Salmonella typhi / immunology*
  • Spleen / cytology
  • Typhoid-Paratyphoid Vaccines / toxicity

Substances

  • Antigens, Bacterial
  • Polysaccharides
  • Typhoid-Paratyphoid Vaccines
  • Dactinomycin
  • Complement System Proteins