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Stat Med. 1985 Oct-Dec;4(4):521-6.

Interim analyses in clinical trials: classical vs. Bayesian approaches.

Abstract

This paper concerns interim analysis in clinical trials involving two treatments from the points of view of both classical and Bayesian inference. I criticize classical hypothesis testing in this setting and describe and recommend a Bayesian approach in which sampling stops when the probability that one treatment is the better exceeds a specified value. I consider application to normal sampling analysed in stages and evaluate the gain in average sample number as a function of the number of interim analyses.

PMID:
4089353
DOI:
10.1002/sim.4780040412
[Indexed for MEDLINE]

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