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Atherosclerosis. 1985 Nov;57(2-3):337-41.

Subendothelial accumulation of unesterified cholesterol. An early event in atherosclerotic lesion development.

Abstract

This preliminary report describes the simplest and possibly earliest lipid-containing lesions induced in aortas of rabbits fed a cholesterol-containing diet. Subendothelial accumulation of unesterified cholesterol, detected with filipin dye, appears to precede morphologic changes in endothelium and accumulation of subendothelial lipid-containing "foam" cells. The origin of subendothelial unesterified cholesterol remains to be determined.

PMID:
4084363
[Indexed for MEDLINE]
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