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Med Hypotheses. 1985 Sep;18(1):19-28.

Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II): a common genotype linked to oncogenes?

Abstract

We hypothesize that: hereditary nonpolyposis colorectal cancer (HNPCC) accounts for a significant proportion of the colon cancer burden; the premalignant colonic mucosa in HNPCC patients may be comparable in many respects to the premalignant polyps in its hereditary multiple adenomatous polyposis counterpart; and finally, study of HNPCC colonic mucosa may harbor important clues for elucidation of the multistep process of carcinogenesis, including relationships between activated oncogenes, genetics, and environmental perturbations.

PMID:
4069033
DOI:
10.1016/0306-9877(85)90115-x
[Indexed for MEDLINE]

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