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Comp Biochem Physiol B. 1985;82(1):79-85.

Chain-length specificities of mitochondrial and peroxisomal beta-oxidation of fatty acids in livers of rainbow trout (Salmo gairdneri).


Peroxisomes and mitochondria were prepared from livers of rainbow trout fed diets containing either 15% crude fish oil (CFO) or 11.5% partially hydrogenated fish oil (PHFO) plus 3.5% CFO. Peroxisomal preparations from the two dietary groups showed similar rates and substrate specificity patterns for acyl-CoA oxidation. The peroxisomal oxidation rate was highest with 12:0-CoA and decreased with increasing chain length, being negligible with 22-carbon acyl-CoA's. The trans isomer of 18:1(n-9) was oxidized at a higher rate than the cis isomer only by peroxisomes from the PHFO + CFO group. Mitochondria prepared from both groups of fish exhibited a broad chain-length specificity for the oxidation of acylcarnitines. Both polyunsaturated and trans monoenoic fatty acids were readily oxidized.

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