Abstract
The minimum inhibitory concentration values for a group of synthesized heterocyclic derivatives of 1-methyl-1-nitroethyl sulphide were determined for Gram-positive and Gram-negative bacteria, yeast, and fungi. The active compounds were further screened. The effect of these compounds on growth, morphology and incorporation of 3H-uridine was also tested. Comments on the possible model of action of such compounds is included.
MeSH terms
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Anti-Bacterial Agents
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Anti-Infective Agents / pharmacology*
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Cell Survival / drug effects
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Disulfides / metabolism
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Fungi / drug effects
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Microbial Sensitivity Tests
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Nitro Compounds / metabolism
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Nitro Compounds / pharmacology*
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Species Specificity
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Structure-Activity Relationship
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Transcription, Genetic / drug effects
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Disulfides
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Nitro Compounds