DNA flow cytometry in human testicular cancer

Cancer Lett. 1985 Aug;28(1):55-60. doi: 10.1016/0304-3835(85)90092-8.

Abstract

DNA flow cytometry revealed aneuploid tumour stemlines in 19 of 20 primary testicular cancers without significant difference of the ploidy values between seminomas and non-seminomas. In 7 of 8 analyzable histograms the S-phase activity was 22-51%. A metastatic mature teratoma had 6% cells in S-phase. These results support the clinical observation that testicular cancer is usually a rapidly growing human tumour. The high percentage of aneuploidy in testicular cancer may be of clinical value in the diagnosis of this malignancy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA, Neoplasm / analysis*
  • Flow Cytometry*
  • Humans
  • Male
  • Testicular Neoplasms / analysis*
  • Testicular Neoplasms / pathology

Substances

  • DNA, Neoplasm