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Biometrics. 1985 Mar;41(1):295-301.

Testing the statistical certainty of a response to increasing doses of a drug.

Abstract

Experiments in which the treatments are composed of a series of doses of a compound and a zero dose control are often used in animal toxicity studies. A test procedure is proposed to assess trends in the response variable. The notion of a no-statistical-significance-of-trend (NOSTASOT) dose is introduced, and questions of multiplicity of statistical tests in this context are addressed.

PMID:
4005384
[PubMed - indexed for MEDLINE]
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