Further studies on the mechanism of fat-free diet (FFD)--protection against indomethacin-induced intestinal ulcers in the rat

Proc Soc Exp Biol Med. 1985 May;179(1):113-5. doi: 10.3181/00379727-179-42072.

Abstract

A fat-free diet (FFD) reduces bacterial flora when compared to a regular diet (RD) in rats. FFD reduces the degree and incidence of indomethacin-induced intestinal ulceration concomitantly with a reduction in bacterial flora overgrowth produced by the drug. Present and previous findings indicate that diminished deconjugation of indomethacin and reduction of intestinal flora overgrowth play a major role in the ulcer-preventing properties of FFD.

MeSH terms

  • Animals
  • Dietary Fats / administration & dosage*
  • Indomethacin / metabolism
  • Indomethacin / toxicity*
  • Intestinal Diseases / chemically induced
  • Intestinal Diseases / microbiology
  • Intestinal Diseases / prevention & control*
  • Intestines / microbiology*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Ulcer / chemically induced
  • Ulcer / microbiology
  • Ulcer / prevention & control

Substances

  • Dietary Fats
  • Indomethacin