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Mech Ageing Dev. 1985 Feb;29(2):143-9.

Intramitotic variation in proliferative potential: stochastic events in cellular aging.

Abstract

A series of mitotic pairs of cells were isolated and the proliferative potential of each cell determined. Although the proliferative potentials of the two cells of a single pair were similar for most pairs examined, in a significant proportion large differences were observed. These results suggest a strong stochastic component in the somatic inheritance of proliferative potential. This observation provides the basis for refinement of a mathematical model for in vitro cellular aging.

PMID:
3974307
[Indexed for MEDLINE]

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