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Hum Genet. 1986 Jan;72(1):25-6.

A possible new type of chromosome rearrangement: telomere-centromere translocation (tct) followed by double duplication.


The reassessment of a case of complex interchromosomal rearrangement after breakage at centromeric and telomeric regions, and the comparison with four other independently published cases suggested the existence of a new type of rearrangement. It would consist of: formation of an isochromosome after breakage at a centromeric region, duplication of the telomeric region of another chromosome, and reassociation of the nonduplicated arm of the first chromosome with the duplicated telomeric region of the second chromosome.

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