Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms

Science. 1985 Mar 1;227(4690):1044-7. doi: 10.1126/science.3919442.

Abstract

A human complementary DNA clone specific for the alpha-chain of the T-cell receptor and a panel of rodent X human somatic cell hybrids were used to map the alpha-chain gene to human chromosome 14 in a region proximal to the immunoglobulin heavy chain locus. Analysis by means of in situ hybridization of human metaphase chromosomes served to further localize the alpha-chain gene to region 14q11q12, which is consistently involved in translocations and inversions detectable in human T-cell leukemias and lymphomas. Thus, the locus for the alpha-chain T-cell receptor may participate in oncogene activation in T-cell tumors.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromosome Mapping*
  • Chromosomes, Human, 13-15
  • DNA / genetics
  • Genes
  • Humans
  • Hybrid Cells / metabolism
  • Immunoglobulin Heavy Chains / genetics*
  • Immunoglobulin alpha-Chains / genetics*
  • Leukemia / genetics
  • Lymphoma / genetics
  • Mice
  • Nucleic Acid Hybridization
  • Receptors, Antigen, T-Cell / genetics*
  • T-Lymphocytes
  • Translocation, Genetic

Substances

  • Immunoglobulin Heavy Chains
  • Immunoglobulin alpha-Chains
  • Receptors, Antigen, T-Cell
  • DNA

Associated data

  • GENBANK/K02777