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Nature. 1985 Dec 12-18;318(6046):533-8.

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice.


Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at several stages of B-cell maturation. These myc mice should aid study of lymphoma development, B-cell ontogeny and immunoglobulin regulation.

[Indexed for MEDLINE]

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