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J Rheumatol. 1985 Aug;12(4):735-7.

Penicillamine in ankylosing spondylitis: a double blind placebo controlled trial.


A double blind placebo controlled trial was carried out over a 6-month period on 17 patients with ankylosing spondylitis (AS) to assess the effect of the second line antirheumatic drug, D-penicillamine. The patients included 13 with peripheral joint involvement. No significant improvement over placebo was detected in a variety of clinical and laboratory indices in the patients receiving active treatment. This controlled trial would not support a use for penicillamine in AS.

[Indexed for MEDLINE]

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