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Eur J Biochem. 1985 Jun 3;149(2):401-4.

Mutations affecting the enzymes involved in the utilization of 4-aminobutyric acid as nitrogen source by the yeast Saccharomyces cerevisiae.


We present genetic evidence for the enzymes 4-aminobutyrate: 2-oxoglutarate aminotransferase (EC and succinate-semialdehyde dehydrogenase [NAD(P)+] (EC constituting the functional pathway for the utilization of 4-aminobutyric acid as a nitrogen source by Saccharomyces cerevisiae. We show that the pathway is induced by 4-aminobutyric acid and that the presence of the pathway enzymes probably requires the integrity of a positive control element.

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