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J Gen Microbiol. 1985 Apr;131(4):775-80.

Mechanism of action of nikkomycin and the peptide transport system of Candida albicans.

Abstract

Nikkomycin was found to be a potent growth inhibitor of Candida albicans through competitive inhibition of chitin synthase [Ki = 0.16 microM (0.1 microgram ml-1)]. The activity of the peptide-nucleoside drug was antagonized by both peptone and defined peptides. Transported dipeptides were effective antagonists while transported oligopeptides were not. A mutant of C. albicans resistant to the effects of nikkomycin through a transport defect was unable to transport dipeptides, while oligopeptide uptake was apparently unaffected. At least two peptide permeases are operational in this organism.

PMID:
3886837
DOI:
10.1099/00221287-131-4-775
[Indexed for MEDLINE]

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