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Eksp Onkol. 1985;7(2):56-60.

[Evaluation of leukemogenic and immunogenic properties of leukemic cells modified by neuraminidase of non-cholera Vibrios on the model of Rauscher leukemia].

[Article in Russian]


The leukemogenic activity of modified leukemic cells was studied in experiments on the 385 BALB/c mice with Rauscher leukemia by transplantation of different amount of treated cells. Immunogenicity of modified leukemic cells was estimated under conditions of three-fold immunization of animals 2 days later by the cells dose equal to 1.10(6) which began 24 h after the leukemia transplantation. The effect of immunotherapy of neuraminidase-modified leukemic cells results in elongation of animal lifetime, presence of less pronounced changes in the peripheral blood and spleen as well as in stimulation of cell immunity factors.

[Indexed for MEDLINE]

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