Abstract
Three cases of vincristine-induced gastrointestinal toxicity were treated with metoclopramide. Two patients had severe abdominal pain and adynamic ileus, while the third had severe constipation and abdominal bloating. Rapid resolution of symptoms occurred in all three patients. Metoclopramide may, therefore, prove useful in the treatment of these not infrequent toxic effects of vinca alkaloids.
MeSH terms
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Aged
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Constipation / chemically induced
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Gastrointestinal Motility / drug effects
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Humans
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Intestinal Obstruction / chemically induced*
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Intestinal Obstruction / drug therapy
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Leukemia, Lymphoid / drug therapy
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Leukemia, Myeloid / drug therapy
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Male
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Metoclopramide / therapeutic use*
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Middle Aged
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Pain
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Prednisone / therapeutic use
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Vincristine / adverse effects*
Substances
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Vincristine
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Metoclopramide
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Prednisone