Send to

Choose Destination

Salt sensitivity in normotensives with and salt resistance in normotensives without heredity of hypertension.


We have studied blood pressure responses to moderate sodium restriction from 200 to 50 mmol/day over 2 weeks in 62 normotensive subjects with and without a family history of hypertension by continuous automatic blood pressure recording. Based on the average of the blood pressure of 1 hour continuous monitoring under basal conditions, we have been able to demonstrate a significant fall of blood pressure in 28 young subjects with a heredity of hypertension after moderate sodium restriction from 200 to 50 mmol over 2 weeks (fall in systolic blood pressure 5.4 +/- 1.1, diastolic 2.5 +/- 0.8, mean blood pressure 2.9 +/- 0.7 mmHg, mean +/- SEM), whereas blood pressure remained unchanged in a group of 34 subjects without heredity of hypertension after moderate sodium restriction (change in systolic blood pressure -1.0 +/- 0.6, diastolic blood pressure -0.6 +/- 0.7 and mean blood pressure -0.93 +/- 0.67 mmHg). 29 of the subjects were studied a third time 2 weeks after having returned to their usual high sodium diet and in those in whom a blood pressure fall was observed during sodium restriction it returned to pre-intervention values. This demonstrates that normotensives with a heredity of hypertension are salt sensitive and adds further evidence that a high sodium intake may be of critical importance for the initiation of essential hypertension.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center