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Biochem Biophys Res Commun. 1985 Sep 16;131(2):974-9.

Cilastatin (MK 0791) is a potent and specific inhibitor of the renal leukotriene D4-dipeptidase.

Abstract

The metabolism of leukotriene D4 to leukotriene E4 by a dipeptidase of kidney tissue is strongly inhibited by cilastatin (MK 0791) a known renal dehydropeptidase-I inhibitor. The comparison with similar enzyme activities from other tissues (liver, lung, serum, polymorphonuclear granulocytes) revealed a high specificity of cilastatin for the kidney enzyme which was found to be associated with the microsomal fraction. The lowest detectable inhibitory concentration of cilastatin within renal tissue was 8 X 10(-8)M.

PMID:
3863619
DOI:
10.1016/0006-291x(85)91335-x
[Indexed for MEDLINE]

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