The influence of binder concentration on the bond formation of pharmaceutical granules

J Pharm Pharmacol. 1979 Jul;31(7):429-33. doi: 10.1111/j.2042-7158.1979.tb13547.x.

Abstract

The formation of particle mucilage bonds with dicalcium phosphate dihydrate and starch mucilage binder reduces the B.E.T. nitrogen adsorption surface are from 196 to 0.96 m2 g-1. The maximum reduction (40%) of granule surface area at a binder concentration of 10% w/w corresponded to similar optima in friability, compressability and median granule size. Surface and pore-void structural analysis by mercury intrusion could not discriminate between pore-void sizes in the range 0.5-100 nm. Nitrogen adsorption measurements showed, however, that the microporous surface area decreased from 0.3 to 0.18 m2 g-1 as binder surface coverage increased over the concentration range 2 to 20% w/w starch mucilage.

MeSH terms

  • Calcium Phosphates
  • Chemistry, Pharmaceutical
  • Drug Compounding / methods
  • Excipients*
  • Pharmaceutical Vehicles*
  • Starch
  • Tablets*

Substances

  • Calcium Phosphates
  • Excipients
  • Pharmaceutical Vehicles
  • Tablets
  • Starch