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Biochem J. 1986 Dec 15;240(3):909-12.

Valine metabolism. Gluconeogenesis from 3-hydroxyisobutyrate.

Abstract

During valine catabolism in muscle both 2-oxoisovalerate and 3-hydroxyisobutyrate can be released into the circulation. 3-Hydroxyisobutyrate is a good gluconeogenic substrate in isolated cortical tubules and hepatocytes. The maximal rate of gluconeogenesis from 3-hydroxyisobutyrate was greater than from 2-oxoisovalerate. We propose that 3-hydroxyisobutyrate is an inter-organ metabolite by which the gluconeogenic potential of valine, whose catabolism has been initiated in muscle, may be conserved.

PMID:
3827880
PMCID:
PMC1147506
[Indexed for MEDLINE]
Free PMC Article

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