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Cancer Treat Rep. 1987 Mar;71(3):261-5.

Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy.


We have identified amplification of the thymidylate synthase gene in a colonic tumor that had developed resistance to 5-fluorouracil/leucovorin combination chemotherapy. The tumor had previously undergone a partial response to this combination but began to progress following a prolonged period of continuous therapy and relative disease stabilization. Since thymidylate synthase is a target enzyme for 5-fluorouracil, it is likely that the observed gene amplification is responsible for the resistance. Thus, gene amplification may be a relevant mechanism of acquired resistance to fluoropyrimidine chemotherapy in the clinic.

[Indexed for MEDLINE]

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